Cardinals vs. Seahawks prediction, odds, spread, injuries, trends for NFL Week 7

A betting preview and best bet for the NFL Week 7 NFC West matchup between the Cardinals and Seahawks.

Seattle Seahawks quarterback Geno Smith (7) throws in the fourth quarter during an NFL football game
Seattle Seahawks quarterback Geno Smith (7) throws in the fourth quarter during an NFL football game / Kareem Elgazzar/The Enquirer / USA TODAY

The Seattle Seahawks had a heartbreaking loss in Week 6, falling to the Bengals despite outplaying them for the majority of the game. Luckily, they have a great opportunity to get back on track in Week 7 against the Arizona Cardinals.

In this article, I'm going to tell you everything you need to know to bet on this game, including why the Seahawks are a great bet to take care of business against Arizona.

For more Week 7 picks, check out our BetSided NFL betting analyst Iain MacMillan’s best bet for every game on the slate here!

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Cardinals vs. Seahawks odds, spread, and total

Cardinals vs. Seahawks betting trends

  • The OVER is 4-1 in the Cardinals last five games
  • Seahawks are 4-1 ATS in their last five games vs. Cardinals
  • Cardinals are 1-10 ATS in their last 11 games vs. NFC West opponents
  • Seahawks are 4-10 ATS in their last 14 games
  • The UNDER is 4-1 in the Seahawks' last five home games
  • Seahawks are 0-5 ATS in their last five games vs. NFC West opponents

Cardinals vs. Seahawks injury reports

Arizona Cardinals injury report

  • Antonio Hamilton Sr. - CB - Questionable
  • Budda Baker - S - IR
  • Elijah Higgins - TE - Questionable
  • Jesse Leketa - LB - Questionable
  • Jalen Thompson - S - Questionable

Seattle Seahawks injury report

  • Coby Bryant - CB - IR
  • Jake Curhan - OT - Questionable
  • Abraham Lucas - OT - IR
  • Artie Burns - CB - Questionable
  • Damien Lewis - G - Questionable

Cardinals vs. Seahawks how to watch

  • Date: Sunday, Oct. 22
  • Game Time: 4:05 p.m. EST
  • Venue: Lumen Field
  • How to Watch (TV): FOX
  • Arizona Cardinals Record: 1-5
  • Seattle Seahawks Record: 3-2

Cardinals vs. Seahawks key players to watch

Arizona Cardinals

Victor Dimukeje: For the Cardinals to have a shot in this game they need to pressure Geno Smith like the Bengals were able to do last week. That means Victor Dimukeje is going to be a key palyer for them this week. He has 3.5 sacks and four tackles for a loss on the season, so if he can continue to disrupt opposing offenses, they have a shot to stay in this game.

Seattle Seahawks

DK Metcalf: The Cardinals biggest weakness is their secondary, which means the key players for the Seahawks are their receivers, including their big-play target, DK Metcalf. He's averaging 15.3 yards per catch and he is well poised to have a field day against Arizona on Sunday.

Cardinals vs. Seahawks prediction and pick

The Cardinals are starting to crash back down to earth after a solid start to their season when they were looking like a frisky team. Now, they're starting to look like who we thought they would. Their metrics have fallen off a cliff over the past two weeks.

The Seahawks are a matchup nightmare for the Cardinals. Arizona's biggest strength is its ability to run the ball, ranking second in the NFL for yards per carry, averaging 5.3 yards per rush. Unfortunately for them, they not face a Seahawks team that has the best opponent yards per carry in the league, keeping teams to just 3.2 yards per rush.

Meanwhile, the biggest weakness for the Cardinals is their secondary, giving up 7.3 yards per throw and 8.4 yards per throw over their last three games. Now, they face a Seahawks offense that ranks inside the top 10 in EPA/dropback and yards per pass attempt.

This is shaping up to be a blowout in favor of the Seahawks.

Odds refresh periodically and are subject to change.

You can check out all of Iain's bets here!